Why I'm Getting SMARTER!
If you've noticed me getting SMARTER ... THIS is why:
This is an answer to the question "Why are there different types of hyperpigmentation (what we used to call "age spots"):
The yellow-brown pigment I was referencing is called lipofuscin, and is the result of cellular detoxification systems declining in their activity or being damaged. Our cells are equipped with their own "cleansing & detox" mechanisms whose role is to get rid of cellular waste. Some of that cellular waste represents oxidized cellular organelles such as mitochondria, for example, or other proteins and lipids within the cell that undergo damage and oxidation. Our cells utilize two main detox mechanisms - proteasomes and autophagy to dispose of these cellular oxidized mechanisms, but even proteasomes and autophagy (which employs lysosomes) slows down with age and oxidative damage. In that case, cellular waste (*AKA oxidized proteins and lipids) clog up the cell, contribute to yellow-brown pigment formation and eventually cellular senescence (cell becoming non-productive, damaging 'zombie-cells".) Addressing pigmentation today is so much more different than before, simply because we know more about what's involved and we have more at our disposal to address all of this.
We are SO FAR AWAY from Mom's Cold Cream days!!!!!!!
So, now you know why my face goes screwy when someone asks me: "Do you have anything for brown spots?" OH, if it were only that simple!
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